Dr. Steffen Möller

Photo of Dr. Steffen  Möller

Head of Bioinformatics Group
Proteome Center Rostock
Schillingallee 69
18057 Rostock

Email: steffen.moeller(at)uni-rostock.de
Phone: +49 381 4 94 49 30
Fax: +49 381 4 94 49 32
 

Research interests

In general, this is any computational tool that supports biological research. The work I personally liked most is

  • GPCR coupling prediction
  • Intergenomics on disease-associated chromosomal loci
  • many more on agents and transmembrane proteins

Current activities involve the computer aided interpretation of what we get from genome-wide SNP studies. And it was these thoughts that guided me into the field of grid computing. Something that albeit having published on is less of a science but more of a promotional nature is my involvement with the Debian Linux distribution. This is bunch of enthusiastic people who mutually help each other and (en passent the world) in maintaining their research infrastructure. This comprises both general IT and bioinformatics applications.

Active Projects

  • EU project "Know ARC" on grid computing. A single look on the Nordu Grid monitor says more than a 1 000 words. I am investigating how grid technologies can become more applicable for bioinformatics:
  • Dynamic Runtime Environments
  • Embedding grid jobs in bioinformatics workflow suite Taverna
  • Expression QTL analysis in a murine model of Multiple Sclerosis 

Others

  • Apical-basolateral distribution of epithelial membrane proteins
  • sugaR - R package for plotting a diabetes diary

Rewards

For my first degree in the early nineties of the last century I was joining some fun competitions that I like to think back about:

  • National Programming Contest, U Texas, Austin, TX, USA
  • 1995 Shocc - Shortest C Contest, Kaiserslautern, Germany

and I had helped with the 1994 MICE (Most Intelligent Corn Eater) competition in Hildesheim, Germany. Since then I contributed to two projects that were rewarded: 

  • 2005 - Intergenomics on QTL (German QUECKENSTEDT Award for research in multiple sclerosis)
  • 2006 - prediction of a pical-basolateral sorting in kidney epithelia (Jugend forscht)

Publikationen

2011

Krishna Kumar Kandaswamy, Kuo-Chen Chou, Thomas Martinetz, Steffen Möller, P. N. Suganthan, S. Sridharan, and Ganesan Pugalenthi,
{AFP}-{P}red: {A} random forest approach for predicting antifreeze proteins from sequence-derived properties, Journal of Theoretical Biology , vol. 270, no. 1, pp. 56--62, 2011.
Bibtex: BibTeX
@article{KaChMaMoSuSrGa11,
author = {Krishna Kumar Kandaswamy and Kuo-Chen Chou and Thomas Martinetz and Steffen M{\"o}ller and P. N. Suganthan and S. Sridharan and Ganesan Pugalenthi},
title = {{AFP}-{P}red: {A} random forest approach for predicting antifreeze proteins from sequence-derived properties},
journal = {Journal of Theoretical Biology},
volume = {270},
number = {1},
pages = {56--62},
year = {2011}
}

2010

Krishna Kumar Kandaswamy, Ganesan Pugalenthi, Steffen Möller, Enno Hartmann, Kai-Uwe Kalies, P.N.Suganthan, and Thomas Martinetz,
Prediction of apoptosis protein locations with {G}enetic {A}lgorithms and {S}upport {V}ector {M}achines through a new mode of pseudo amino acid composition, Protein Peptide Letters , vol. 17, pp. 1473--1479, 2010.
Bibtex: BibTeX
@article{KaPuMoHaKaSuMa10,
author = {Krishna Kumar Kandaswamy and Ganesan Pugalenthi and Steffen M{\"o}ller and Enno Hartmann and Kai-Uwe Kalies and P.N.Suganthan and Thomas Martinetz},
title = {Prediction of apoptosis protein locations with {G}enetic {A}lgorithms and {S}upport {V}ector {M}achines through a new mode of pseudo amino acid composition},
journal = {Protein Peptide Letters},
pages = {1473--1479},
volume = {17},
year = {2010}
}

Krishna Kumar Kandaswamy, Ganesan Pugalenthi, Enno Hartmann, Kai-Uwe Kalies, Steffen Möller, P.N. Suganthan, and Thomas Martinetz,
{SPRED}: {A} machine learning approach for the identification of classical and non-classical secretory proteins in mammalian genomes, Biochemical and biophysical research communications , vol. 391, no. 3, pp. 1306--1311, 2010.
Datei: KaPuHaKaMoSuMa09.pdf
Bibtex: BibTeX
@article{KaPuHaKaMoSuMa10,
author = {Krishna Kumar Kandaswamy and Ganesan Pugalenthi and Enno Hartmann and Kai-Uwe Kalies and Steffen M{\"o}ller and P.N. Suganthan and Thomas Martinetz},
title = {{SPRED}: {A} machine learning approach for the identification of classical and non-classical secretory proteins in mammalian genomes},
journal = {Biochemical and biophysical research communications},
volume = {391},
number = {3},
pages = {1306--1311},
year = {2010},
url = {https://www.inb.uni-luebeck.de/fileadmin/files/publications/inb-publications/pdfs/KaPuHaKaMoSuMa09.pdf}
}

2009

X. Zhou, H. Krabbenhöft, M. Niinimäki, A. Depeuringe, S. Möller, and H. Müller,
An {E}asy {S}etup for {P}arallel {M}edical {I}mage {P}rocessing: {U}sing {T}averna and {ARC}, Stud Health Technol Inform. , vol. 147, pp. 41--50, 2009.
Bibtex: BibTeX
@article{ZhKrNiDeMoMu09,
author = {X. Zhou and H. Krabbenh{\"o}ft and M. Niinim{\"a}ki and A. Depeuringe and S. M{\"o}ller and H. M{\"u}ller},
title = {An {E}asy {S}etup for {P}arallel {M}edical {I}mage {P}rocessing: {U}sing {T}averna and {ARC}},
journal = {Stud Health Technol Inform.},
year = {2009},
volume = {147},
pages = {41--50}
}

2008

Daniel F. Schwarz, Oliver Hädicke, Jeanette Erdmann, Andreas Ziegler, Daniel Bayer, and Steffen Möller,
{SNPtoGO}: characterizing {SNPs} by enriched {GO} terms, Bioinformatics , vol. 24, no. 1, pp. 146--148, 2008.
Datei: btm551v1
Bibtex: BibTeX
@article{ScHaErZiBaMo08,
author = {Daniel F. Schwarz and Oliver H{\"a}dicke and Jeanette Erdmann and Andreas Ziegler and Daniel Bayer and Steffen M{\"o}ller},
title = {{SNPtoGO}: characterizing {SNPs} by enriched {GO} terms},
journal = {Bioinformatics},
year = {2008},
volume = {24},
number = {1},
pages = {146--148},
url = {http://bioinformatics.oxfordjournals.org/cgi/content/abstract/btm551v1}
}

Hajo N. Krabbenhöft, Steffen Möller, and Daniel Bayer,
Integrating {ARC} {G}rid {M}iddleware with {T}averna {W}orkflows, Bioinformatics , vol. 24, no. 9, pp. 1221--1222, 2008.
Bibtex: BibTeX
@article{KrMoBa08,
author = {Hajo N. Krabbenh{\"o}ft and Steffen M{\"o}ller and Daniel Bayer},
title = {Integrating {ARC} {G}rid {M}iddleware with {T}averna {W}orkflows},
journal = {Bioinformatics},
volume = {24},
number = {9},
pages = {1221--1222},
year = {2008},
opt_pmid = 18353787
}

2007

Emanuela Merelli, Giuliano Armano, Nicola Cannata, Flavio Corradini, Mark d'Inverno, Andreas Doms, Phillip Lord, Andrew Martin, Luciano Milanesi, Steffen Möller, Michael Schroeder, and Michael Luck,
Agents in bioinformatics, computational and systems biology., Briefings in Bioinformatics , vol. 8, no. 1, pp. 45--59, 2007.
Bibtex: BibTeX
@article{MeArCaCoInDoLoMaMiMoScLu07,
author = {Emanuela Merelli and Giuliano Armano and Nicola Cannata and Flavio Corradini and Mark d'Inverno and Andreas Doms and Phillip Lord and Andrew Martin and Luciano Milanesi and Steffen M{\"o}ller and Michael Schroeder and Michael Luck},
title = {Agents in bioinformatics, computational and systems biology.},
journal = {Briefings in Bioinformatics},
volume = {8},
number = {1},
year = {2007},
pages = {45--59},
ee = {http://dx.doi.org/10.1093/bib/bbl014},
bibsource = {DBLP, http://dblp.uni-trier.de}
}

Dirk Eddelbuettel, David Vernazobres, Albrecht Gebhardt, and Steffen Möller,
apt-get install cran bioc: {O}n automated builds of 1700 {R} packages for {D}ebian, in use{R} conference , Ames, Iowa , 2007.
Datei:
Bibtex: BibTeX
@inproceedings{EdVeGeMo07,
author = {Dirk Eddelbuettel and David Vernazobres and Albrecht Gebhardt and Steffen M{\"o}ller},
title = {apt-get install cran bioc: {O}n automated builds of 1700 {R} packages for {D}ebian},
booktitle = {use{R} conference},
address= {Ames, Iowa},
year = {2007},
url = {http://user2007.org/}
}

D. Bayer, T. Bhimdi, G. Oechsler, F. Orellana, A. Wäänänen, B. K{\'o}nya, and S. Möller,
Dynamic Runtime Environments for Grid Computing, in Cracow'07 Grid Workshop , Cracow, Poland , 2007. pp. 155--162.
Bibtex: BibTeX
@inproceedings{BaBhOeOrWaKoMo07,
title={Dynamic Runtime Environments for Grid Computing},
author={D. Bayer and T. Bhimdi and G. Oechsler and F. Orellana and A. W{\"a}{\"a}n{\"a}nen and B. K{\'o}nya and S. M{\"o}ller},
address={Cracow, Poland},
booktitle={Cracow'07 Grid Workshop},
pages={155--162},
year={2007}
}

Steffen Möller, Daniel Bayer, David Vernazobres, Albrecht Gebhardt, and Dirk Eddelbuettel,
Scientific Grid Computing via Community-Controlled Autobuilding of Software Packages Across Architectures, in NETTAB , Pisa, Italy , 2007.
Datei:
Bibtex: BibTeX
@inproceedings{MoBaVeGeEd07,
author = {Steffen M{\"o}ller and Daniel Bayer and David Vernazobres and Albrecht Gebhardt and Dirk Eddelbuettel},
title = {Scientific Grid Computing via Community-Controlled Autobuilding of Software Packages Across Architectures},
booktitle = {NETTAB},
address = {Pisa, Italy},
year = {2007},
url = {http://nettab.org/2007/}
}

2006

Robert Goertsches, Pablo Serrano-Fern{\'a}ndez, Steffen Möller, Dirk Koczan, and Uwe K. Zettl,
Multiple {S}clerosis {T}herapy {M}onitoring {B}ased on {G}ene {E}xpression, Curr. Pharm. Des. , vol. 12, no. 29, pp. 3761--3779, 2006.
Datei: art00008
Bibtex: BibTeX
@article{GoeSeMoeKoZe06,
author = {Robert Goertsches and Pablo Serrano-Fern{\'a}ndez and Steffen M{\"o}ller and Dirk Koczan and Uwe K. Zettl},
title = {Multiple {S}clerosis {T}herapy {M}onitoring {B}ased on {G}ene {E}xpression},
journal = {Curr. Pharm. Des.},
year = {2006},
volume = {12},
number = {29},
pages = {3761--3779},
url = {http://www.ingentaconnect.com/content/ben/cpd/2006/00000012/00000029/art00008}
}

Steffen Möller, Uwe K. Zettl, Robert Goertsches, and Pablo Serrano-Fern{\'a}ndez,
Comparative Genomics for the Investigation of Autoimmune Diseases, Curr. Pharm. Des. , vol. 12, no. 29, pp. 3707--3722, 2006.
Datei: art00003
Bibtex: BibTeX
@article{MoeZeGoeSe06,
author = {Steffen M{\"o}ller and Uwe K. Zettl and Robert Goertsches and Pablo Serrano-Fern{\'a}ndez},
title = {Comparative Genomics for the Investigation of Autoimmune Diseases},
journal = {Curr. Pharm. Des.},
year = {2006},
volume = {12},
number = {29},
pages = {3707--3722},
url = {http://www.ingentaconnect.com/content/ben/cpd/2006/00000012/00000029/art00003}
}

X. Yu, K. Bauer P. Wernhoff, D. Koczan, S. Möller, H.-J. Thiesen, and S.M. Ibrahim,
Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line, J. Immunol. , vol. 177, no. 10, pp. 7042--7049, 2006.
Bibtex: BibTeX
@article{YuBaWeKoMoThIb06,
author = {X. Yu and K. Bauer P. Wernhoff and D. Koczan and S. M{\"o}ller and H.-J. Thiesen and S.M. Ibrahim},
title = {Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line},
journal = {J. Immunol.},
year = {2006},
volume = {177},
number = {10},
pages = {7042--7049}
}

Johan Öckinger, Pablo Serrano-Fern{\'a}ndez, Steffen Möller, Saleh M. Ibrahim, Tomas Olsson, and Maja Jagodic,
Definition of a 1.06 Mb region linked to neuroinflammation in humans, rats and mice, Genetics , vol. 173, no. 3, pp. 1539--1545, 2006.
Datei: articlerender.fcgi
Bibtex: BibTeX
@article{OecFeMoeIbOlJa06,
author = {Johan {\"O}ckinger and Pablo Serrano-Fern{\'a}ndez and Steffen M{\"o}ller and Saleh M. Ibrahim and Tomas Olsson and Maja Jagodic},
title = {Definition of a 1.06 Mb region linked to neuroinflammation in humans, rats and mice},
year = {2006},
journal = {Genetics},
volume = {173},
number = {3},
pages = {1539--1545},
url={http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16624898}
}

2005

Steffen Möller, Pablo Serrano-Fern{\'a}ndez, Michael Watson, Dirk Koczan, Vassilis Kotsikoris, Manfred Kunz, Martin Blüggel, Jens Pahnke, Harald Illges, Stefan Mikkat, Hans-Jürgen Thiesen, Michael O. Glocker, Uwe K. Zettl, and Saleh M. Ibrahim,
Collection of soluble variants of membrane proteins for transcriptomics and proteomics., In Silico Biol. , vol. 5, no. 3, pp. 295--311, 2005.
Datei:
Bibtex: BibTeX
@article{MoSeWaKoKoKu05,
author = {Steffen M{\"o}ller and Pablo Serrano-Fern{\'a}ndez and Michael Watson and Dirk Koczan and Vassilis Kotsikoris and Manfred Kunz and Martin Bl{\"u}ggel and Jens Pahnke and Harald Illges and Stefan Mikkat and Hans-J{\"u}rgen Thiesen and Michael O. Glocker and Uwe K. Zettl and Saleh M. Ibrahim},
title = {Collection of soluble variants of membrane proteins for transcriptomics and proteomics.},
journal = {In Silico Biol.},
volume = {5},
number = {3},
pages = {295--311},
year = {2005},
url= {http://www.bioinfo.de/isb/2005/05/0028/}
}

V. Aidinis, P. Carninci, M. Armaka, W. Witke, V. Harokopos, N. Pavelka, D. Koczan, C. Argyropoulos, M.M. Thwin, S. Möller, W. Kazunori, P. Gopalakrishnakone, P. Ricciardi-Castagnoli, H.-J. Thiesen, Y. Hayashizaki, and G. Kollias,
Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis., PLoS Genet. , vol. 1, no. 4, pp. e48, 2005.
Datei: articlerender.fcgi
Bibtex: BibTeX
@article{AiCaArWiHaPaKoArThMoeKaGoRiThHaKo05,
author = {V. Aidinis and P. Carninci and M. Armaka and W. Witke and V. Harokopos and N. Pavelka and D. Koczan and C. Argyropoulos and M.M. Thwin and S. M{\"o}ller and W. Kazunori and P. Gopalakrishnakone and P. Ricciardi-Castagnoli and H.-J. Thiesen and Y. Hayashizaki and G. Kollias},
title = {Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.},
journal = {PLoS Genet.},
volume = {1},
number = {4},
pages = {e48},
year = {2005},
url = {http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16254600}
}

A. Tille, and S. Möller,
Debian-{M}ed {F}ree {S}oftware in {H}ealth {C}are, in MAS*BIOMED Workshop, AAMAS, Utrecht, NL , Guiliano Admano and Jörg Denzinger and Andrew Martin and Emanuela Merelli and Simon Miles and Huaglory Tianfield and Rainer Unland, Eds. 2005. pp. 72--85.
Datei: proceedings.pdf
Bibtex: BibTeX
@inproceedings{TiMo05,
author = {A. Tille and S. M{\"o}ller},
title = {Debian-{M}ed {F}ree {S}oftware in {H}ealth {C}are},
booktitle = {MAS*BIOMED Workshop, AAMAS, Utrecht, NL},
editor = {Guiliano Admano and J{\"o}rg Denzinger and Andrew Martin and Emanuela Merelli and Simon Miles and Huaglory Tianfield and Rainer Unland},
pages = {72--85},
year = {2005},
url = {http://people.debian.org/~tille/debian-med/talks/200507_biomed/index_en.html},
url = {http://www.diee.unica.it/biomed05/pdf/proceedings.pdf}
}

P. Gierer, S. M. Ibrahim, T. Mittlmeier, D. Koczan, S. Möller, J. Landes, G. Gradl, and B. Vollmar,
Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis, Arthritis Research and Therapy , no. 7, pp. R868--R876, 2005.
Datei: ar1754.pdf
Bibtex: BibTeX
@misc{GiIbMiKoMo05,
author = {P. Gierer and S. M. Ibrahim and T. Mittlmeier and D. Koczan and S. M{\"o}ller and J. Landes and G. Gradl and B. Vollmar},
title = {Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis},
journal = {Arthritis Research and Therapy},
number = {7},
pages = {R868--R876},
year = {2005},
url = {http://arthritis-research.com/content/7/4/R868},
url = {http://arthritis-research.com/content/pdf/ar1754.pdf}
}

M. Johannesson, L. M. Olsson, A. K. Lindqvist, S. Möller, D. Koczan, L. Wester-Rosenlof, H. J. Thiesenand S. Ibrahim, and R. Holmdahl,
Gene expression profiling of arthritis using a {QTL} chip reveals a complex gene regulation of the {Cia5} region in mice, Genes Immun. , vol. 6, pp. 575--583, 2005.
Datei: 6364242a.html
Bibtex: BibTeX
@article{JoOlLiMoKoWeThIbHo05,
author = {M. Johannesson and L. M. Olsson and A. K. Lindqvist and S. M{\"o}ller and D. Koczan and L. Wester-Rosenlof and H. J. Thiesenand S. Ibrahim and R. Holmdahl},
title = {Gene expression profiling of arthritis using a {QTL} chip reveals a complex gene regulation of the {Cia5} region in mice},
journal = {Genes Immun.},
volume = {6},
year = {2005},
pages= {575--583},
url = {http://www.nature.com/gene/journal/v6/n7/abs/6364242a.html}
}

P. Serrano-Fern{\'a}ndez, S. M. Ibrahim, D. Koczan, U. K. Zettl, and S. Möller,
In silico fine-mapping: narrowing disease-associated loci by intergenomics, Bioinformatics , vol. 21, no. 8, pp. 1737--1738, 2005.
Datei: 1737
Bibtex: BibTeX
@article{SeIbKoZeMo05,
author = {P. Serrano-Fern{\'a}ndez and S. M. Ibrahim and D. Koczan and U. K. Zettl and S. M{\"o}ller},
title = {In silico fine-mapping: narrowing disease-associated loci by intergenomics},
journal = {Bioinformatics},
volume = {21},
number = {8},
pages = {1737--1738},
year = {2005},
url = {http://bioinformatics.oxfordjournals.org/cgi/content/full/21/8/1737}
}

E. Bartocci, E. Merelli, and S. Möller,
"Integration of EnsEMBL with BioAgent." 2005.
Bibtex: BibTeX
@techreport{BaMeMoe05,
author = {E. Bartocci and E. Merelli and S. M{\"o}ller},
title = {Integration of EnsEMBL with BioAgent.},
journal = {Technical Report},
number = {TR02-2005},
institution = {Dipartimento di Matematica e Informatica, Universita di Camerino},
year = {2005}
}