Dr. Steffen Möller
Head of Bioinformatics Group
Proteome Center Rostock
Schillingallee 69
18057 Rostock
Email: | steffen.moeller(at)uni-rostock.de |
Phone: | +49 381 4 94 49 30 |
Fax: | +49 381 4 94 49 32 |
Research interests
In general, this is any computational tool that supports biological research. The work I personally liked most is
- GPCR coupling prediction
- Intergenomics on disease-associated chromosomal loci
- many more on agents and transmembrane proteins
Current activities involve the computer aided interpretation of what we get from genome-wide SNP studies. And it was these thoughts that guided me into the field of grid computing. Something that albeit having published on is less of a science but more of a promotional nature is my involvement with the Debian Linux distribution. This is bunch of enthusiastic people who mutually help each other and (en passent the world) in maintaining their research infrastructure. This comprises both general IT and bioinformatics applications.
Active Projects
- EU project "Know ARC" on grid computing. A single look on the Nordu Grid monitor says more than a 1 000 words. I am investigating how grid technologies can become more applicable for bioinformatics:
- Dynamic Runtime Environments
- Embedding grid jobs in bioinformatics workflow suite Taverna
- Expression QTL analysis in a murine model of Multiple Sclerosis
Others
- Apical-basolateral distribution of epithelial membrane proteins
- sugaR - R package for plotting a diabetes diary
Rewards
For my first degree in the early nineties of the last century I was joining some fun competitions that I like to think back about:
- National Programming Contest, U Texas, Austin, TX, USA
- 1995 Shocc - Shortest C Contest, Kaiserslautern, Germany
and I had helped with the 1994 MICE (Most Intelligent Corn Eater) competition in Hildesheim, Germany. Since then I contributed to two projects that were rewarded:
- 2005 - Intergenomics on QTL (German QUECKENSTEDT Award for research in multiple sclerosis)
- 2006 - prediction of a pical-basolateral sorting in kidney epithelia (Jugend forscht)
Publikationen
2011
{AFP}-{P}red: {A} random forest approach for predicting antifreeze proteins from sequence-derived properties, Journal of Theoretical Biology , vol. 270, no. 1, pp. 56--62, 2011.
2010
Prediction of apoptosis protein locations with {G}enetic {A}lgorithms and {S}upport {V}ector {M}achines through a new mode of pseudo amino acid composition, Protein Peptide Letters , vol. 17, pp. 1473--1479, 2010.
{SPRED}: {A} machine learning approach for the identification of classical and non-classical secretory proteins in mammalian genomes, Biochemical and biophysical research communications , vol. 391, no. 3, pp. 1306--1311, 2010.
Datei: | KaPuHaKaMoSuMa09.pdf |
Bibtex: | @article{KaPuHaKaMoSuMa10, author = {Krishna Kumar Kandaswamy and Ganesan Pugalenthi and Enno Hartmann and Kai-Uwe Kalies and Steffen M{\"o}ller and P.N. Suganthan and Thomas Martinetz}, title = {{SPRED}: {A} machine learning approach for the identification of classical and non-classical secretory proteins in mammalian genomes}, journal = {Biochemical and biophysical research communications}, volume = {391}, number = {3}, pages = {1306--1311}, year = {2010}, url = {https://www.inb.uni-luebeck.de/fileadmin/files/publications/inb-publications/pdfs/KaPuHaKaMoSuMa09.pdf} } |
2009
An {E}asy {S}etup for {P}arallel {M}edical {I}mage {P}rocessing: {U}sing {T}averna and {ARC}, Stud Health Technol Inform. , vol. 147, pp. 41--50, 2009.
2008
{SNPtoGO}: characterizing {SNPs} by enriched {GO} terms, Bioinformatics , vol. 24, no. 1, pp. 146--148, 2008.
Datei: | btm551v1 |
Bibtex: | @article{ScHaErZiBaMo08, author = {Daniel F. Schwarz and Oliver H{\"a}dicke and Jeanette Erdmann and Andreas Ziegler and Daniel Bayer and Steffen M{\"o}ller}, title = {{SNPtoGO}: characterizing {SNPs} by enriched {GO} terms}, journal = {Bioinformatics}, year = {2008}, volume = {24}, number = {1}, pages = {146--148}, url = {http://bioinformatics.oxfordjournals.org/cgi/content/abstract/btm551v1} } |
Integrating {ARC} {G}rid {M}iddleware with {T}averna {W}orkflows, Bioinformatics , vol. 24, no. 9, pp. 1221--1222, 2008.
2007
Agents in bioinformatics, computational and systems biology., Briefings in Bioinformatics , vol. 8, no. 1, pp. 45--59, 2007.
apt-get install cran bioc: {O}n automated builds of 1700 {R} packages for {D}ebian, in use{R} conference , Ames, Iowa , 2007.
Dynamic Runtime Environments for Grid Computing, in Cracow'07 Grid Workshop , Cracow, Poland , 2007. pp. 155--162.
Scientific Grid Computing via Community-Controlled Autobuilding of Software Packages Across Architectures, in NETTAB , Pisa, Italy , 2007.
2006
Multiple {S}clerosis {T}herapy {M}onitoring {B}ased on {G}ene {E}xpression, Curr. Pharm. Des. , vol. 12, no. 29, pp. 3761--3779, 2006.
Datei: | art00008 |
Bibtex: | @article{GoeSeMoeKoZe06, author = {Robert Goertsches and Pablo Serrano-Fern{\'a}ndez and Steffen M{\"o}ller and Dirk Koczan and Uwe K. Zettl}, title = {Multiple {S}clerosis {T}herapy {M}onitoring {B}ased on {G}ene {E}xpression}, journal = {Curr. Pharm. Des.}, year = {2006}, volume = {12}, number = {29}, pages = {3761--3779}, url = {http://www.ingentaconnect.com/content/ben/cpd/2006/00000012/00000029/art00008} } |
Comparative Genomics for the Investigation of Autoimmune Diseases, Curr. Pharm. Des. , vol. 12, no. 29, pp. 3707--3722, 2006.
Datei: | art00003 |
Bibtex: | @article{MoeZeGoeSe06, author = {Steffen M{\"o}ller and Uwe K. Zettl and Robert Goertsches and Pablo Serrano-Fern{\'a}ndez}, title = {Comparative Genomics for the Investigation of Autoimmune Diseases}, journal = {Curr. Pharm. Des.}, year = {2006}, volume = {12}, number = {29}, pages = {3707--3722}, url = {http://www.ingentaconnect.com/content/ben/cpd/2006/00000012/00000029/art00003} } |
Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line, J. Immunol. , vol. 177, no. 10, pp. 7042--7049, 2006.
Definition of a 1.06 Mb region linked to neuroinflammation in humans, rats and mice, Genetics , vol. 173, no. 3, pp. 1539--1545, 2006.
Datei: | articlerender.fcgi |
Bibtex: | @article{OecFeMoeIbOlJa06, author = {Johan {\"O}ckinger and Pablo Serrano-Fern{\'a}ndez and Steffen M{\"o}ller and Saleh M. Ibrahim and Tomas Olsson and Maja Jagodic}, title = {Definition of a 1.06 Mb region linked to neuroinflammation in humans, rats and mice}, year = {2006}, journal = {Genetics}, volume = {173}, number = {3}, pages = {1539--1545}, url={http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16624898} } |
2005
Collection of soluble variants of membrane proteins for transcriptomics and proteomics., In Silico Biol. , vol. 5, no. 3, pp. 295--311, 2005.
Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis., PLoS Genet. , vol. 1, no. 4, pp. e48, 2005.
Datei: | articlerender.fcgi |
Bibtex: | @article{AiCaArWiHaPaKoArThMoeKaGoRiThHaKo05, author = {V. Aidinis and P. Carninci and M. Armaka and W. Witke and V. Harokopos and N. Pavelka and D. Koczan and C. Argyropoulos and M.M. Thwin and S. M{\"o}ller and W. Kazunori and P. Gopalakrishnakone and P. Ricciardi-Castagnoli and H.-J. Thiesen and Y. Hayashizaki and G. Kollias}, title = {Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.}, journal = {PLoS Genet.}, volume = {1}, number = {4}, pages = {e48}, year = {2005}, url = {http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16254600} } |
Debian-{M}ed {F}ree {S}oftware in {H}ealth {C}are, in MAS*BIOMED Workshop, AAMAS, Utrecht, NL , Guiliano Admano and Jörg Denzinger and Andrew Martin and Emanuela Merelli and Simon Miles and Huaglory Tianfield and Rainer Unland, Eds. 2005. pp. 72--85.
Datei: | proceedings.pdf |
Bibtex: | @inproceedings{TiMo05, author = {A. Tille and S. M{\"o}ller}, title = {Debian-{M}ed {F}ree {S}oftware in {H}ealth {C}are}, booktitle = {MAS*BIOMED Workshop, AAMAS, Utrecht, NL}, editor = {Guiliano Admano and J{\"o}rg Denzinger and Andrew Martin and Emanuela Merelli and Simon Miles and Huaglory Tianfield and Rainer Unland}, pages = {72--85}, year = {2005}, url = {http://people.debian.org/~tille/debian-med/talks/200507_biomed/index_en.html}, url = {http://www.diee.unica.it/biomed05/pdf/proceedings.pdf} } |
Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis, Arthritis Research and Therapy , no. 7, pp. R868--R876, 2005.
Datei: | ar1754.pdf |
Bibtex: | @misc{GiIbMiKoMo05, author = {P. Gierer and S. M. Ibrahim and T. Mittlmeier and D. Koczan and S. M{\"o}ller and J. Landes and G. Gradl and B. Vollmar}, title = {Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis}, journal = {Arthritis Research and Therapy}, number = {7}, pages = {R868--R876}, year = {2005}, url = {http://arthritis-research.com/content/7/4/R868}, url = {http://arthritis-research.com/content/pdf/ar1754.pdf} } |
Gene expression profiling of arthritis using a {QTL} chip reveals a complex gene regulation of the {Cia5} region in mice, Genes Immun. , vol. 6, pp. 575--583, 2005.
Datei: | 6364242a.html |
Bibtex: | @article{JoOlLiMoKoWeThIbHo05, author = {M. Johannesson and L. M. Olsson and A. K. Lindqvist and S. M{\"o}ller and D. Koczan and L. Wester-Rosenlof and H. J. Thiesenand S. Ibrahim and R. Holmdahl}, title = {Gene expression profiling of arthritis using a {QTL} chip reveals a complex gene regulation of the {Cia5} region in mice}, journal = {Genes Immun.}, volume = {6}, year = {2005}, pages= {575--583}, url = {http://www.nature.com/gene/journal/v6/n7/abs/6364242a.html} } |
In silico fine-mapping: narrowing disease-associated loci by intergenomics, Bioinformatics , vol. 21, no. 8, pp. 1737--1738, 2005.
Datei: | 1737 |
Bibtex: | @article{SeIbKoZeMo05, author = {P. Serrano-Fern{\'a}ndez and S. M. Ibrahim and D. Koczan and U. K. Zettl and S. M{\"o}ller}, title = {In silico fine-mapping: narrowing disease-associated loci by intergenomics}, journal = {Bioinformatics}, volume = {21}, number = {8}, pages = {1737--1738}, year = {2005}, url = {http://bioinformatics.oxfordjournals.org/cgi/content/full/21/8/1737} } |
"Integration of EnsEMBL with BioAgent." 2005.